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Trial Design

This trial has been powered to detect a 15% clinically relevant improvement in surgical site infection for soft tissue sarcoma resection. This requires 80 per arm including loss to follow up.

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Intervention group: 5 days NPWT (ActiVAC - KCI, Texas, USA) 

Control group: Absorbent dressings (as per local protocol)

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Inclusion criteria:

Adults (16 and over)

Soft tissue sarcoma undergoing curative resection

Primary closure

English speaking

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Exclusion criteria:

None primary closure

Unable to consent
Children
Post radiation sarcomas or sarcoma in presence of active infection
Multiple metastatic disease

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Outcomes:

1. Surgical site infection (endpoint 30 days)

2. Time to wound dryness

3. Surgical drain volume

4. Adverse Events

5. Function:

  - Toronto Extremity Salvage Score (TESS)

  - Musculoskeletal Society Score (MSTS)

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