Negative Pressure Wound Therapy (NPWT) has been used for open wound defects for several decades. Recent evaluation has shown clinical improvement with its use in high risk, primarily closed, surgical wounds. This pragmatic randomised control trial is evaluating the clinical improvement in surgical site infection using NPWT versus standard absorbent dressings.
This initial phase is powered to evaluate the dressing in soft tissue sarcomas undergoing resection. Future phases will evaluate cases using endoprosthetic implants and amputations.
The principle investigating centre is Glasgow Royal Infirmary, based in the west of Scotland, UK.
Initial pilot data from a case controlled trial, showed a significantly improved wound breakdown rate with the use of NPWT*
*R.Kong, D.W. Shields, O.Bailey, S.Gupta, A.Mahendra, 'Negative Pressure Wound Therapy for Closed Surgical Wounds in Musculoskeletal Oncology Patients - A Case-Control Trial'. The Open Orthopaedics Journal 2017, Vol 11, p502-507. DOI: 10.2174/1874325001711010502